Numerous people look for a “cannabis store near me” to buy marijuana, whether for therapeutic reasons or for enjoyment. Many are aware that cannabis products may help alleviate issues like anxiety, depression, pain, nausea, and vomiting. Have you thought about its impact on gastrointestinal disorders?
Table of Contents
- Key Takeaways:
- Gastrointestinal Disorders and cannabis Plant
- The Impact of the Plant
- Cannabis Sativa for GI Issues
- Conclusion
- Frequently Asked Questions
- What can you expect when buying from online cannabis stores?
- What is the measurement unit when buying from a cannabis website?
- What distinguishes cannabis for medical use from that used recreationally?
- Are there ready-made joints available in a cannabis store?
- Do cannabis online stores have a physical shop?
Key Takeaways:
- Cannabinoids in the plant interact through the endocannabinoid system in the GI tract.
- cannabis and pain medications can assist in managing Irritable Bowel Syndrome symptoms.
- Online Dispensary Canada Shop offers various cannabis Sativa products, recognized for both recreational and medical use.
Gastrointestinal Disorders and cannabis Plant
The dietary impact of nutraceuticals on gastrointestinal (GI) health is well-documented. Certain diets may help prevent or alleviate various GI conditions. Researchers have isolated and studied the food components responsible for these benefits.
Among the plant-derived nutraceuticals that may aid in treating GI disorders are those from cannabis. cannabis refers to preparations sourced from the cannabis Sativa plant, a fragrant annual flowering herb.
John M. McPartland noted in a scientific review that the Cannabaceae family includes Cannabis, Humulus, and Celtis. Within the cannabis genus, Sativa comprises three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, cannabis Sativa serves multiple purposes, including fiber production, oil extraction, and primarily, recreational or medicinal applications.
The Impact of the Plant
Receptors and ligands of the endocannabinoid system are distributed throughout various areas and systems, important for regulating GI functions. The presence of cannabinoid receptors allows cannabinoids, including non-psychoactive phytocannabinoids, to modulate GI functions in both health and disease. The ECS plays a role in motility, secretion, epithelial barrier function, and viscerosensitivity.
Irritable Bowel Syndrome (IBS)
IBS has various contributing factors, affecting 10–20% of individuals in developed nations, and presents as functional gastrointestinal disturbances without clear organic origins.
The enhancement of cannabinoids’ antinociceptive properties in the presence of inflammation emphasizes the ECS’s significance in visceral hypersensitivity. This insight not only clarifies the mechanisms behind IBS and other GI disorders but also opens promising therapeutic avenues for alleviating abdominal and visceral pain.
Cannabinoids alone may not significantly reduce visceral hypersensitivity in IBS patients. Investigating combinations with other pain-modulating agents, such as opioids, is a compelling alternative worth exploring.
Inflammatory Bowel Disease (IBD)
IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex GI condition influenced by environmental, genetic, and epigenetic factors.
Cannabidiol exhibits strong anti-inflammatory properties across various intestinal inflammation models in mice and rats, as discussed in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD showed a dose-dependent improvement in disease indicators:
- Reduction of structural damage
- Mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.
A study from the Inflammatory Diseases Journal notes the primary finding of their investigation was the challenging tolerability of the botanical extract, with 90% of patients reporting treatment-related adverse effects compared to 48% on placebo.
A trend toward improved quality of life scores and a positive shift in patients’ overall impressions was observed in their per-protocol analysis. The authors speculate that the CBD-rich botanical extract may offer therapeutic benefits to those who can tolerate its effects.
Gastrointestinal Cancer
GI cancers, such as colorectal cancer (CRC), are among the most commonly diagnosed conditions.
Various studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, enhance endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.
Research confirmed CBD’s chemopreventive properties through in vivo models focusing on AOM-induced colon cancer. At a dosage of 1 mg/kg, CBD significantly reduced ACF by 67%, and the number of tumors and polyps decreased by 66% and 57%, respectively. Increasing the dosage to 5 mg/kg showed efficacy primarily in preventing polyp formation.
THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.
Nausea and Vomiting
Positive effects of CBD are observed when combined with THC, as noted in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic effects may arise from the indirect stimulation of somatodendritic 5-HT1A receptors in the dorsal raphe nucleus, potentially leading to reduced 5-HT release in specific brain regions.
Gastroesophageal Reflux Disease (GERD)
Cannabinoids inhibit transient LES relaxations via a CB1-dependent mechanism in both dogs and ferrets, as shown in a study from the Journal of cannabis and Cannabinoid Research. This finding is significant since transient LES relaxations are the primary mechanism underlying gastroesophageal reflux disease.
Cannabis Sativa for GI Issues
Conclusion
Numerous studies suggest that the benefits of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive molecules like CBD, which have received less attention. The cannabis plant interacts with the GI system via the ECS to initiate various functions that can help manage symptoms of certain GI conditions.
Frequently Asked Questions
What can you expect when buying from online cannabis stores?
- Purchasing cannabis products in Canada online offers a wide range of options, featuring both classic favorites and new arrivals.
- You can look forward to added benefits such as promotions, secure payment options, and shipping services to most provinces.
- Essential resources, like a blog or contact page, are available to provide customers with insights or support during their shopping experience.
- During the buying process, you must verify your age by showing identification.
- Some stores include taxes in the total price of products, while others calculate them at checkout.
- Some dispensaries accept online payments like Interac E-Transfer, while others offer cash on delivery.
What is the measurement unit when buying from a cannabis website?
There are two main measurement forms: metric and imperial units. On a cannabis site, you’ll find measurements in grams or ounces, allowing you to locate products like 3.5 grams or 1/8 ounces.
What distinguishes cannabis for medical use from that used recreationally?
Medical cannabis and recreational cannabis come from the same plant species, but their differing effects and intended uses differentiate them. Medical cannabis acts as a therapeutic aid for specific health conditions, typically with a higher CBD content than its recreational counterpart.
Are there ready-made joints available in a cannabis store?
Yes. These come as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient for those who prefer their cannabis ready to use. There is a growing trend in the popularity of pre-rolled joints infused with cannabis concentrates.
Do cannabis online stores have a physical shop?
Not all online stores have physical locations, meaning you can receive your purchases directly at home instead of needing to pick them up from a physical store after placing an online order.
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