Cachexia is a multifaceted condition characterized by persistent muscle loss that cannot be entirely remedied through standard nutritional support, resulting in a decline in functionality. It may be masked by excess weight, obesity, edema, or tumor mass. Anorexia denotes a diminished appetite, often observed in cancer patients, although its precise prevalence remains uncertain.
When cachexia primarily arises from reduced intake, it is referred to as cancer-related cachexia and anorexia syndrome (CACS), which encompasses muscle wasting, lipolysis, and decreased food intake, contrasting with simple cachexia.
Some researchers suggest that cannabis from Online Dispensary Canada Shop could enhance appetite and alleviate nausea in cancer patients.
Table of Contents
Key Takeaways:
- THC capsules may assist cancer patients in increasing food intake and reducing feelings of nausea, thus enhancing their quality of life.
- Studies indicate that cannabis can influence brain cells responsible for hunger management, potentially aiding appetite issues in cancer patients and others.
- THC capsules are precise, convenient, discreet, and durable. They are suitable for medical marijuana users who prefer not to smoke.
Cancer Cachexia and Anorexia Syndrome
Cachexia is a condition identified by significant weight loss resulting from muscle and fat depletion, frequently seen in individuals with advanced diseases such as heart failure, HIV/AIDS, COPD, kidney failure, and particularly cancer.
This often occurs alongside anorexia, which leads to a minimum of 5% weight loss. Together, they constitute cancer anorexia-cachexia syndrome (CACS).
Hospitalized cancer patients typically exhibit inadequate dietary intake, with nearly half being malnourished or at risk. Cachexia not only reduces the quality of life for patients but also complicates treatment and can hasten the end of life. Its incidence escalates as death nears, with cachexia identified as the leading cause of death in over 20% of cases.
Despite its prevalence, CACS frequently goes unrecognized and untreated in clinical environments due to ambiguous definitions, diagnostic criteria, classification systems, and approved treatments. Clinicians evaluate a patient’s nutritional status through various metrics like body weight, skin fold thickness, and mid-arm circumference, although body weight is often relied upon, typically using unsuitable reference weights.
Treatment
The most apparent method to tackle anorexia is to enhance nutrition; however, evidence supporting its efficacy is limited. For cancer patients, nutritional care entails:
- Dietary Counseling
- Oral Supplements
- Enteral and Parenteral Nutrition
Success rates vary depending on the type and stage of cancer.
Pharmacological Approaches
Currently, there are no validated medications specifically for treating Cancer Anorexia-Cachexia Syndrome (CACS), but some drugs are used off-label or are undergoing clinical trials. These medications are categorized based on their mechanisms:
- Appetite Stimulants
- Cytokine Modulators
- Anabolic Agents
- Combination Therapies
Additionally, megestrol acetate, a progestin, is utilized separately due to its unclear mechanism of action.
Cannabis in Medicine
The cannabinoid could significantly enhance the lives of cancer patients, paving the way for future therapies. This offers hope for cachexia patients, a condition where they experience loss of appetite and malnutrition. It provides relief without intoxicating effects, presenting a potential solution for these patients.
Various cannabis formulations with distinct effects are available, such as inhaled THC for rapid onset and brief effects and orally ingested THC for slower absorption and prolonged effects. Sublingual administration provides a quick onset and lasts for 2 to 4 hours.
Clinical Trial
A study conducted by researchers from Israel and the United States evaluated how cannabis pills affect CACS in advanced cancer patients. This discovery holds significant implications for treating appetite disorders faced by cancer patients, individuals with anorexia, and potentially those with obesity.
Methods
They utilized cannabis capsules containing two types of oil-based compounds. They intended to administer 10 mg doses twice daily for six months, which included 9.5 mg of tetrahydrocannabinol (THC) and 0.5 mg of cannabidiol (CBD).
If participants experienced side effects, the dose was reduced to 5 mg twice daily (4.75 mg THC and 0.25 mg CBD). At each medical appointment, participants were weighed. The primary objective was for participants to gain at least 10% more weight than their initial weight.
Results
Out of 24 patients who consented to participate, 17 began treatment with cannabis capsules. However, only 11 continued taking the capsules for more than two weeks. By the study’s conclusion, 3 out of 6 patients who completed the treatment achieved the primary objective of gaining at least 10% more weight, while the weight of the remaining three patients remained unchanged.
Tumor necrosis factor-α (TNF-α), an inflammation marker, decreased following treatment. Patients reported improved appetite and mood, along with reduced pain and fatigue.
Despite several challenges, this preliminary study demonstrated a 10% or greater weight gain in 3 out of 17 patients (17.6%) taking daily doses of 5 mg once or twice without significant side effects. These results support conducting a larger, more controlled study on cannabis capsules in patients with CACS.
Cannabis Capsules
If you prefer edibles, cannabis flowers, or classic pre-rolls, exploring new ways to enjoy cannabis is always thrilling.
THC capsules are among the newest additions to the cannabis market. These capsules are cannabis pills containing a precise dose of THC, derived from a concentrated cannabis extract and a neutral oil. They are akin to cannabis tinctures in capsule form (also known as cannabis oil capsules or THC pills).
Key Components
- Cannabis Extract: This concentrated extract is obtained from the cannabis plant using a method selected by the manufacturer. THC capsules are rich in THC; however, some may contain only CBD or varying CBD/THC ratios.
- Neutral Oil Suspension: THC is not soluble in water, so it is suspended in an oil for effective absorption by the body. The most common oils used are Online Dispensary Canada Shop, aiding digestion and absorption.
Benefits
Medical marijuana patients and recreational users can gain advantages from cannabis capsules. They offer:
- Convenience: Taking a cannabis capsule is as simple as any other oral supplement. Just swallow it with water, no fuss.
- Precision Dosage: For medical users, precise control over cannabinoid intake is crucial for achieving desired effects. With THC capsules, each dose is measured, removing uncertainty.
- Smoke-Free Option: Many individuals prefer to avoid smoking or vaping for personal or health reasons. THC capsules provide a smoke-free alternative, suitable for those with respiratory concerns.
- Longer Effects: Capsules typically deliver longer-lasting effects compared to smoking or vaping, making them ideal for sustained symptom relief over several hours.
Cannabis Capsules vs. Other Forms of Medicinal Cannabis
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Frequently Asked Questions
What are the different types of capsules?
Another benefit of cannabis pills/capsules is their versatility – formulators can create various capsule types for consumers to select from. This means you can find capsules tailored to your personal preference.
- 1:1 Capsules: These capsules provide an equal ratio of THC to CBD in each dose, made with sativa or indica strains and available in various concentrations like 5 mg, 20 mg, 50 mg, or 100 mg cannabinoids per capsule.
- 3:1 Capsules: These capsules offer a ratio of 3 parts CBD to 1 part THC in each dose.
- THC Capsules: These capsules consist solely of THC, with varying concentrations per capsule, produced from different Sativa or Indica strains for specific effects.
- CBD Capsules: These contain only CBD, with no THC, thus not causing mind-altering effects. They are designed for individuals seeking the benefits of CBD exclusively.
How do capsules interact with your body?
- The capsule’s outer shell disintegrates in your digestive tract once consumed.
- The capsule’s contents are absorbed into the bloodstream.
- THC (and other cannabinoids) are metabolized in the liver.
How long does it take for cannabis capsule effects to kick in?
Typically, THC capsules take about 90 minutes to begin exhibiting effects. The effects can persist for 5 to 12 hours, gradually diminishing in intensity. Compared to inhaled cannabis, capsule effects generally last twice as long on average.
However, experiences may vary based on factors such as age, medications, personal cannabis tolerance, and cannabinoid composition. Some users also report differing effects based on specific cannabinoids present, potentially due to the “entourage effect.”
How to mail order marijuana?
To mail order recreational cannabis, locate a trustworthy delivery service online that offers the best quality cannabis products. After selecting your items, choose “order cannabis delivery,” and a delivery driver will safely bring your order. Ensure the service is reputable for a smooth purchasing process.
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